Però dice che la somministrazione c'è stata
si, ma se apri il paper, nell'abstract dice questo:
Recently, the world has been dealing with a devastating global pandemic coronavirus infection, with more than 12 million infected worldwide and over 300,000 deaths as of May 15th 2020, related to a novel coronavirus (2019-nCoV), characterized by a spherical morphology and identified through next-generation sequencing. Although the respiratory tract is the primary portal of entry of SARS-CoV-2, gastrointestinal involvement associated with nausea, vomiting and diarrhoea may also occur. No drug or vaccine has been approved due to the absence of evidence deriving from rigorous clinical trials. Increasing interest has been highlighted on the possible preventative role and adjunct treatment of lactoferrin, glycoprotein of human secretions part of a non-specific defensive system, known to play a crucial role against microbial and viral infections and exerting anti-inflammatory effects on different mucosal surfaces and able to regulate iron metabolism. In this review, analysing lactoferrin properties, we propose designing a clinical trial to evaluate and verify its effect using a dual combination treatment with local, solubilized intranasal spray formulation and oral administration. Lactoferrin could counteract the coronavirus infection and inflammation, acting either as natural barrier of both respiratory and intestinal mucosa or reverting the iron disorders related to the viral colonization.
poi leggi, e trovi:
However, Lf did not block the virus entry by the direct interaction of spike protein with ACE-2, the functional receptor of both SARS-CoV [83] and SARS-CoV-2 [41]. The current accepted model suggests that Lf could block viral entry by interacting with heparan sulfate proteoglycans (HSPGs), which mediate the transport of extracellular virus particles from the low affinity anchoring sites to the high affinity specific entry as ACE-2 [84]. Taken together, these results suggest that Lf could play a protective role in host defence against SARS-CoV-2 infection through binding to HSPGs, thus blocking the early interaction between SARS-CoV-2 and host cells.
e concludono
Taken together, we believe that all these properties justify designing a clinical trial to evaluate and verify if a local treatment of nasal mucosa with Lf solubilized in an intra-nasal spray formulation, and oral assumption of Lf, could counteract the coronavirus infection and inflammation. Lf acts either as a natural barrier of both respiratory and intestinal mucosa or reverting the iron disorders related to the viral colonization or modulating the immune response or down-regulating the pro-inflammatory cytokines released by the viral inflammation, without any risk of possible adverse events. Furthermore, the inclusion of Lf in preserving structures, such as liposomes, reduces gastric and intestinal denaturation while maintaining its integrity and therefore its biological functionality [95]. Lf could be used in asymptomatic or mildly symptomatic patients to prevent the worsening of SARS-CoV2. The Lf ideal dosage should be diversified on the basis of symptom severity. Asymptomatic COVID-19 patients should use 300 mg, orally administered, doubling the dosage (maximum 1gr) for mildly symptomatic patients [67]. We suggest maintaining the treatment at least until the COVID-19 buffer becomes negative.
tutte le citazioni nelle conclusioni sono vecchie.
in sintesi, articolo fuffa per prendere qualche finanziamento covid.
